Qualifying P-glycoprotein in drug-resistant ovarian cancer cells: a dual-mode aptamer probe approach-Reference-Cited by-同舟云学术

Qualifying P-glycoprotein in drug-resistant ovarian cancer cells: a dual-mode aptamer probe approach

Published:2024 Issue:15 Volume:149 Page:3928-3938
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Pang Chaobin¹,Xu Heng²³,Xu Jichao¹,Zhang Lei¹,Wang Jinhua⁴⁵,Jing Su¹^ORCID

Affiliation:

1. School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China

2. Jiangsu Provincial Institute of Materia Medica, Nanjing Tech University, Nanjing, 211816, China

3. Nanjing Health Run Biotechnology Co., Ltd, Nanjing, 211316, China

4. Department of Gynecological Oncology Surgery, Jiangsu Cancer Hospital (Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital), 42 Baiziting Road, Nanjing 210009, Jiangsu Province, China

5. Department of Gynaecology, NO.1 Hospital of Xining, 10 Huzhuxiang Road, Xining 810099, Qinghai Province, China

Abstract

Our dual-mode FI and FP aptamer probe detects P-glycoprotein in drug-resistant ovarian cancer cells, demonstrating high specificity and sensitivity with detection limits of 1.13 nM and 40 cells per mL, promising improved diagnosis strategies.

Funder

National Natural Science Foundation of China

Jiangsu Provincial Key Research and Development Program

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/AN/D4AN00803K

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