Synthesis, in vitro and in vivo anticancer activities of novel 4-substituted 1,2-bis(4-chlorophenyl)-pyrazolidine-3,5-dione derivatives-Reference-Cited by-同舟云学术

Synthesis, in vitro and in vivo anticancer activities of novel 4-substituted 1,2-bis(4-chlorophenyl)-pyrazolidine-3,5-dione derivatives

Published:2015 Issue:10 Volume:6 Page:1781-1786
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Zhang Xu-Yao¹²³⁴⁵,Gu Yi-Fei¹²³⁴⁵,Chen Ting¹²³⁴⁵,Yang Dong-Xiao¹²³⁴⁵,Wang Xi-Xin¹²³⁴⁵,Jiang Bai-Ling¹²³⁴⁵,Shao Kun-Peng¹²³⁴⁵,Zhao Wen¹²³⁴⁵,Wang Cong¹²³⁴⁵,Wang Jun-Wei¹²³⁴⁵,Zhang Qiu-Rong¹²³⁴⁵,Liu Hong-Min¹²³⁴⁵

Affiliation:

1. Key Laboratory of Advanced Pharmaceutical Technology

2. Ministry of Education of China

3. Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety

4. School of Pharmaceutical Sciences

5. Zhengzhou University

Abstract

To develop potent and selective anticancer agents, a series of novel 4-substituted 1,2-bis(4-chlorophenyl)-pyrazolidine-3,5-dione derivatives were designed and synthesized.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C5MD00240K

Reference15 articles.

1. Synthesis of 8-Hydroxyquinoline Derivatives as Novel Antitumor Agents

2. Pyrazolidine-3,5-dione derivatives as potent non-steroidal agonists of farnesoid X receptor: Virtual screening, synthesis, and biological evaluation

3. Pyrazolidine-3,5-diones and 5-Hydroxy-1H-pyrazol-3(2H)-ones, Inhibitors of UDP-N-acetylenolpyruvyl Glucosamine Reductase

4. QSAR analysis of pyrazolidine-3,5-diones derivatives as Dyrk1A inhibitors

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