Avoiding pitfalls in L1-regularised inference of gene networks-Reference-Cited by-同舟云学术

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Avoiding pitfalls in L1-regularised inference of gene networks

Published:2015 Issue:1 Volume:11 Page:287-296
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Tjärnberg Andreas¹²³⁴⁵,Nordling Torbjörn E. M.¹²³⁴⁶,Studham Matthew¹²³⁴,Nelander Sven⁶⁷⁸⁹¹⁰,Sonnhammer Erik L. L.¹²³⁴⁵

Affiliation:

1. Stockholm Bioinformatics Centre

2. Science for Life Laboratory

3. 17121 Solna

4. Sweden

5. Department of Biochemistry and Biophysics

6. Department of Immunology

7. Genetics and Pathology

8. Uppsala University

9. Rudbeck laboratory

10. 75185 Uppsala

Abstract

L₁ regularisation methods fail to infer the correct network even when the data are so informative that all existing links can be proven to exist.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MB/C4MB00419A

Reference38 articles.

1. Inferring Genetic Networks and Identifying Compound Mode of Action via Expression Profiling

2. A network biology approach to aging in yeast

3. A Yeast Synthetic Network for In Vivo Assessment of Reverse-Engineering and Modeling Approaches

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