Toward the synthesis of the hypoxia selective anticancer agent BE-43547 A2-Reference-Cited by-同舟云学术

Toward the synthesis of the hypoxia selective anticancer agent BE-43547 A2

Published:2021 Issue:45 Volume:19 Page:9833-9839
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Kranthikumar Ramagonolla¹²^ORCID

Affiliation:

1. Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India

2. Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA

Abstract

The stereoselective synthesis of the 19-epi-BE-43547 A2 chiral framework is achieved from d-glucose by employing an unusual (Z)-selective Julia–Kocienski olefination and hydroboration as key steps.

Funder

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01824H

Reference26 articles.

1. COVID-19 and Cancer: Current Challenges and Perspectives

2. The Impact of COVID-19 on Cancer Risk and Treatment

3. Hypoxia: A key feature of COVID-19 launching activation of HIF-1 and cytokine storm

4. APD-Containing Cyclolipodepsipeptides Target Mitochondrial Function in Hypoxic Cancer Cells

5. The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy

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1. Dual hypoxia-responsive supramolecular complex for cancer target therapy;Nature Communications;2023-09-13

2. Julia‐Kocienski Olefination in the Synthesis of Trisubstituted Alkenes: Recent Progress;European Journal of Organic Chemistry;2023-08-17

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