Total synthesis and stereochemical assignment of rakicidin F-Reference-Cited by-同舟云学术

Total synthesis and stereochemical assignment of rakicidin F

Published:2022 Issue:20 Volume:20 Page:4135-4140
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Han Fangzhi¹,Liu Guangju¹,Zhao Xiuhe¹,Du Shunshun¹,Ding Yahui²,Zhang Quan¹,Deng Huiting³,Wang Liang²^ORCID,Chen Yue²^ORCID

Affiliation:

1. The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, 300350, People's Republic of China

2. College of Chemistry, Nankai University, Tianjin, 300071, People's Republic of China

3. Nankai University, Tianjin Third Central Hospital affiliated to Nankai University, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Institute of Hepatobiliary Disease, Tianjin, 300170, People's Republic of China

Abstract

Total synthesis of rakicidin F was accomplished and its unknown absolute configuration of stereogenic centers was confirmed.

Funder

Natural Science Foundation of Tianjin City

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00692H

Reference27 articles.

1. Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

2. Rakicidins, New Cytotoxic Lipopeptides from Micromonospora sp. Fermentation, Isolation and Characterization.

3. Complete Stereochemistry and Preliminary Structure–Activity Relationship of Rakicidin A, a Hypoxia-Selective Cytotoxin from Micromonospora sp.

4. Rakicidins G - I, cyclic depsipeptides from marine Micromonospora chalcea FIM 02-523

5. Rakicidin C, A New Cyclic Depsipeptide fromStreptomycessp.

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