Oxamusplatin: a cytotoxic Pt(ii) complex of a nitrogen mustard with resistance to thiol based sequestration displays enhanced selectivity towards cancer
Author:
Affiliation:
1. Department of Chemical Sciences and Centre for Advanced Functional Materials
2. Indian Institute of Science Education and Research Kolkata
3. Mohanpur-741246
4. India
5. Department of Biological Sciences
Abstract
Oxamusplatin shows enhanced selectivity towards cancer, targets cellular DNA, disrupts the microtubule network and strongly resists sequestration by deactivating agents, glutathione, ATP7B or phosphoglycoproteins.
Funder
Science and Engineering Research Board
The Wellcome Trust DBT India Alliance
Publisher
Royal Society of Chemistry (RSC)
Subject
Inorganic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/DT/C9DT04269E
Reference53 articles.
1. Human cancer databases (Review)
2. Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects
3. The resurgence of platinum-based cancer chemotherapy
4. Modulation of the reactivity of nitrogen mustards by metal complexation: approaches to modify their therapeutic properties
5. The Biological Actions and Therapeutic Applications of the B-Chloroethyl Amines and Sulfides
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