Piperidine carbamate peptidomimetic inhibitors of the serine proteases HGFA, matriptase and hepsin-Reference-Cited by-同舟云学术

Piperidine carbamate peptidomimetic inhibitors of the serine proteases HGFA, matriptase and hepsin

Published:2019 Issue:9 Volume:10 Page:1646-1655
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Damalanka Vishnu C.¹²³⁴^ORCID,Wildman Scott A.⁵⁶⁷⁸⁴^ORCID,Janetka James W.¹²³⁴^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biophysics

2. Washington University School of Medicine

3. St. Louis

4. USA

5. University of Wisconsin Carbone Cancer Center

6. Drug Development Core

7. University of Wisconsin-Madison

8. Madison

Abstract

A series of piperidine-based peptidomimetic inhibitors have been synthesized and evaluated their activity against the three serine proteases HGFA, matriptase, and hepsin. All analogs showed nanomolar activity against matriptase and hepsin.

Funder

Susan G. Komen for the Cure

Washington University in St. Louis

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00234K

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