Synthesis and crystal characteristics of nirmatrelvir-Reference-Cited by-同舟云学术

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Synthesis and crystal characteristics of nirmatrelvir

Published:2023 Issue:7 Volume:8 Page:1747-1759
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Jiang Bibo¹,Li Gang¹,Yu Jun¹,Xu Xiaoyan¹,Pan Hongjuan¹,Zhao Chuanmeng¹,Zhong Jialiang¹^ORCID,Zhang Fuli¹

Affiliation:

1. Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 201203, Shanghai, China

Abstract

Several synthetic routes of nirmatrelvir (the ingredient of a new drug to treat COVID-19 made by Pfizer) have been reported.

Funder

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RE/D3RE00019B

Reference18 articles.

1. An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

2. A. D.Lee , J.Andy and K.Walter , US Pat. , 11124497, 2021

3. A. D.Lee , J.Andy and K.Walter , US Pat. , 11174231, 2021

4. D. R.Owen , M. Y.Pettersson , M. R.Reese , M. F.Sammons , J. B.Tuttle and Q.Yang , WO Pat. , 2022013684, 2022

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Tale of Two Polymorphs: Investigating the Structural Differences and Dynamic Relationship between Nirmatrelvir Solid Forms (Paxlovid);Molecular Pharmaceutics;2024-07-25

2. Nirmatrelvir: From Discovery to Modern and Alternative Synthetic Approaches;Processes;2024-06-17

3. Green Chemistry Considerations in the Synthesis of Nirmatrelvir, the Active Pharmaceutical Ingredient (API) in Paxlovid™;Reference Module in Chemistry, Molecular Sciences and Chemical Engineering;2024

4. The dissolution mechanism, molecular dynamics simulation and thermodynamic analysis of nirmatrelvir (treatment of COVID-19) in aqueous ethanol mixtures;Journal of Molecular Liquids;2023-12

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