Tale of Two Polymorphs: Investigating the Structural Differences and Dynamic Relationship between Nirmatrelvir Solid Forms (Paxlovid)
Author:
Affiliation:
1. Pfizer Worldwide R&D, Groton, Connecticut 06340, United States
2. Pfizer Worldwide R&D, Sandwich CT13 9ND, U.K.
3. XtalPi Inc, Cambridge, Massachusetts 02142, United States
Publisher
American Chemical Society (ACS)
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.3c01074
Reference68 articles.
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2. An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19
3. Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19
4. Development of the Commercial Manufacturing Process for Nirmatrelvir in 17 Months
5. Drug Development Process; Food and Drug Administration. https://www.fda.gov/patients/learn-about-drug-and-device-approvals/drug-development-process (accessed July 10, 2024).
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