Multitarget-directed resveratrol derivatives: anti-cholinesterases, anti-β-amyloid aggregation and monoamine oxidase inhibition properties against Alzheimer's disease-Reference-Cited by-同舟云学术

Multitarget-directed resveratrol derivatives: anti-cholinesterases, anti-β-amyloid aggregation and monoamine oxidase inhibition properties against Alzheimer's disease

Published:2014 Issue:5 Volume:5 Page:609-616
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Pan Long-Fei¹²³⁴⁵,Wang Xiao-Bing¹²³⁴⁵,Xie Sai-Sai¹²³⁴⁵,Li Su-Yi¹²³⁴⁵,Kong Ling-Yi¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Natural Medicines

2. Department of Natural Medicinal Chemistry

3. China Pharmaceutical University

4. Nanjing 210009

5. People's Republic of China

Abstract

Resveratrol derivatives were designed and synthesized as multitarget-directed agents for treating AD, and 6r was a balanced inhibitor toward all the tested targets.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MD/C3MD00376K

Reference42 articles.

1. Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors

2. The Cholinergic Hypothesis of Geriatric Memory Dysfunction

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4. Combating Alzheimer's Disease With Multifunctional Molecules Designed for Metal Passivation

5. Tau protein kinases: Involvement in Alzheimer's disease

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