Design, synthesis, and biological evaluation of 1,2,4-oxadiazole-based derivatives as multitarget anti-Alzheimer agents

Author:

Ayoup Mohammed Salah12ORCID,Barakat Mohamed Reda2,Abdel-Hamid Hamida2,Emam Ehab3,Al-Faiyz Yasair S.1ORCID,Masoud Aliaa A.4,Ghareeb Doaa A.45,Sonousi Amr67,Kassab Asmaa E.6ORCID

Affiliation:

1. Department of Chemistry, College of Science, King Faisal University, P.O. Box 400, Al-Ahsa 31982, Saudi Arabia

2. Chemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria, 21321, Egypt

3. General Q.C Manager, Alexandria company for pharmaceuticals, Alexandria 21521, Egypt

4. Bio-screening and Preclinical Trial Lab, Biochemistry Department, Faculty of Science, Alexandria University, 21511, Alexandria, Egypt

5. Center of Excellence for Drug Preclinical Studies (CE-DPS), Pharmaceutical and Fermentation Industry Development Center, City of Scientific Research & Technological Applications (SRTA-city), New Borg El Arab, Alexandria, Egypt

6. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, P.O. Box 11562, Kasr El-Aini Street, Cairo, Egypt

7. University of Hertfordshire hosted by Global Academic Foundation, New Administrative Capital, Cairo, Egypt

Abstract

A series of novel 1,2,4-oxadiazole-based derivatives were synthesized and evaluated for their potential anti-Alzheimer disease activity.

Funder

Deanship of Scientific Research, King Faisal University

Publisher

Royal Society of Chemistry (RSC)

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