Microscopic local stiffening in a supramolecular hydrogel network expedites stem cell mechanosensing in 3D and bone regeneration-Reference-Cited by-同舟云学术

Microscopic local stiffening in a supramolecular hydrogel network expedites stem cell mechanosensing in 3D and bone regeneration

Published:2021 Issue:6 Volume:8 Page:1722-1734
ISSN:2051-6347
Container-title:Materials Horizons
language:en
Short-container-title:Mater. Horiz.

Author:

Yuan Weihao¹²³⁴,Wang Haixing⁵²³⁴,Fang Chao⁶⁷⁸⁴,Yang Yongkang⁵²³⁴,Xia Xingyu⁶⁷⁸⁴,Yang Boguang¹²³⁴,Lin Yuan⁶⁷⁸⁴^ORCID,Li Gang⁵²³⁴,Bian Liming¹²³⁴⁹^ORCID

Affiliation:

1. Department of Biomedical Engineering

2. The Chinese University of Hong Kong

3. Sha Tin, New Territories

4. China

5. Department of Orthopaedic and Traumatology

6. Department of Mechanical Engineering

7. The University of Hong Kong

8. Pok Fo Lam

9. Shenzhen Research Institute

Abstract

A cell-adaptable hydrogel containing microscopically local stiffening structures shows a heterogeneous and hierarchical hydrogel network topology, thereby facilitating the 3D stellate spreading of stem cells and promoting the bone regeneration.

Funder

Research Grants Council, University Grants Committee

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrical and Electronic Engineering,Process Chemistry and Technology,Mechanics of Materials,General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MH/D1MH00244A

Reference62 articles.

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2. Dynamic Regulation of the Structure and Functions of Integrin Adhesions

3. Matrix Elasticity Directs Stem Cell Lineage Specification