Organophotocatalytic α-deuteration of unprotected primary amines <i>via</i> H/D exchange with D<sub>2</sub>O-Reference-Cited by-同舟云学术

Organophotocatalytic α-deuteration of unprotected primary amines via H/D exchange with D₂O

Published:2024 Issue:3 Volume:60 Page:296-299
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Meng Xiang¹,Dong Yue¹,Liu Qiangqiang¹,Wang Wei¹²³^ORCID

Affiliation:

1. Department of Pharmacology and Toxicology, R. Ken Coit College of Pharmacy, University of Arizona, USA

2. Department of Chemistry and Biochemistry, University of Arizona, USA

3. University of Arizona Cancer Centre, University of Arizona, 1703 E. Mabel Street, Tucson, AZ 85721-0207, USA

Abstract

Harnessing the α-amino radical reactivity enables achieving a direct H/D exchange reaction with unmasked primary amines for cost-effective synthesis of α-deuterated products.

Funder

National Institute of General Medical Sciences

University of Arizona

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D3CC04634F

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