Dehalogenative deuteration of alkyl and aryl bromides by thiyl radical catalysis under visible-light irradiation-Reference-Cited by-同舟云学术

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Dehalogenative deuteration of alkyl and aryl bromides by thiyl radical catalysis under visible-light irradiation

Published:2024 Issue:42 Volume:60 Page:5526-5529
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Lee Jiin¹,Lee Sunggi¹²^ORCID

Affiliation:

1. Department of Physics and Chemistry, DGIST, Daegu 42988, Republic of Korea

2. Center for Basic Science, DGIST, Daegu 42988, Republic of Korea

Abstract

Herein, we report a mild and practical method for the deuteration of alkyl and aryl bromides by a thiyl radical catalyst and halogen-atom transfer (XAT) using disulfides and silanes under visible-light irradiation.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D4CC00474D

Reference61 articles.

1. Applications of Deuterium in Medicinal Chemistry

2. Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences

3. Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development

4. Using Deuterium in Drug Discovery: Leaving the Label in the Drug

5. Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties

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