Diagnosis of penicillin allergy: a MOFs-based composite hydrogel for detecting β-lactamase in serum-Reference-Cited by-同舟云学术

Diagnosis of penicillin allergy: a MOFs-based composite hydrogel for detecting β-lactamase in serum

Published:2019 Issue:2 Volume:55 Page:241-244
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Lian Xiao¹²³⁴⁵,Yan Bing¹²³⁴⁵^ORCID

Affiliation:

1. Shanghai Key Lab of Chemical Assessment and Sustainability

2. School of Chemical Science and Engineering

3. Tongji University

4. Shanghai 200092

5. China

Abstract

A MOFs-based composite hydrogel 1@SA is presented for the diagnosis of penicillin anaphylaxis. This composite hydrogel reflects the enzymatic hydrolysis profiles of penicillin via β-lactamase. The determination of β-lactamase by this hydrogel was achieved through an “ON–OFF–OFF–ON” fluorescence trigger pattern. The potency of 1@SA was further demonstrated for its selectivity, sensitivity and convenient visual detection.

Funder

National Natural Science Foundation of China

Tongji University

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C8CC08245F

Reference42 articles.

1. The penicillins today.

2. A Self-Immobilizing and Fluorogenic Probe for β-Lactamase Detection

3. Allergy to penicillin

4. Penicillin Allergy and Desensitization in Serious Infections during Pregnancy

5. Exploring the chemistry of penicillin as a β-lactamase-dependent prodrug

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