Total synthesis of (±)-tanshinol B, tanshinone I, and (±)-tanshindiol B and C-Reference-Cited by-同舟云学术

Total synthesis of (±)-tanshinol B, tanshinone I, and (±)-tanshindiol B and C

Published:2018 Issue:18 Volume:16 Page:3376-3381
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wang Fan¹²³⁴⁵,Yang Hong⁶⁷⁸⁹⁴,Yu Shujuan¹²³⁴⁵,Xue Yu⁵¹⁰⁷⁸⁹,Fan Zhoulong⁵¹⁰⁷⁸⁹,Liang Gaolin¹²³⁴^ORCID,Geng Meiyu⁶⁷⁸⁹⁴,Zhang Ao⁵¹⁰⁷⁸⁹^ORCID,Ding Chunyong⁵¹⁰⁷⁸⁹^ORCID

Affiliation:

1. Nano Science and Technology Institute

2. University of Science and Technology of China

3. Suzhou 215123

4. China

5. CAS Key Laboratory of Receptor Research

6. State key Laboratory of Drug Research

7. Shanghai Institute of Materia Medica

8. Chinese Academy of Sciences

9. Shanghai 201203

10. Synthetic Organic & Medicinal Chemistry

Abstract

A concise and efficient approach was established for the divergent total synthesis of (±)-tanshinol B, (±)-tanshindiol B, (±)-tanshindiol C, and tanshinone I in 17–50% overall yield over 3–6 steps.

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

Science and Technology Commission of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00567B

Reference34 articles.

1. J. A. Duke and E. S.Avensu , Medicinal Plants of China , 1985 , vol. 2 , p. 381