Tanshinones and their Derivatives: Heterocyclic Ring-Fused Diterpenes of Biological Interest

Author:

Estolano-Cobián Arturo1ORCID,Alonso Mariana Macías2ORCID,Díaz-Rubio Laura1ORCID,Ponce Cecilia Naredo2,Córdova-Guerrero Iván1ORCID,Marrero Joaquín G.2ORCID

Affiliation:

1. Facultad de Ciencias Quiımicas e Ing, Universidad Autonoma de Baja California, Clz. Universidad 14418, Parque Industrial Internacional, Tijuana, B. C. CP 22390, Mexico

2. Instituto Politecnico Nacional, UPIIG, Av. Mineral de Valenciana, No. 200, Col. Fracc, Industrial Puerto Interior, C.P. 36275 Silao de la Victoria, Guanajuato, Mexico

Abstract

The available scientific literature regarding tanshinones is very abundant, and after its review, it is noticeable that most of the articles focus on the properties of tanshinone I, cryptotanshinone, tanshinone IIA, sodium tanshinone IIA sulfonate and the dried root extract of Salvia miltiorrhiza (Tan- Shen). However, although these products have demonstrated important biological properties in both in vitro and in vivo models, their poor solubility and bioavailability have limited their clinical applications. For these reasons, many studies have focused on the search for new pharmaceutical formulations for tanshinones, as well as the synthesis of new derivatives that improve their biological properties. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2015) on tanshinones in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we offer an update on the last five years of new research on these quinones, focusing on their synthesis, biological activity on noncommunicable diseases and drug delivery systems, to support future research on its clinical applications.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology,General Medicine

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