An efficient synthesis of fluoro-neplanocin A analogs using electrophilic fluorination and palladium-catalyzed dehydrosilylation

Author:

Jarhad Dnyandev B.12345,Jang Min Hwan12345,Shin Young Sup12345,Kim Gyudong12345ORCID,Kim Hong-Rae12345,Hyun Young Eum12345,Yoon Ji-seong12345,Jeong Lak Shin12345ORCID

Affiliation:

1. Research Institute of Pharmaceutical Sciences

2. College of Pharmacy

3. Seoul National University

4. Seoul 08826

5. Korea

Abstract

An alternative and efficient approach to neplanocin A analogs 1b and 1d has been developed using electrophilic fluorination and Pd-catalyzed dehydrosilylation.

Funder

National Research Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Reference30 articles.

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2. Studies on neplanocin A,new antitumor antibiotic. II. Structure determination.

3. Structure and Function of S-Adenosylhomocysteine Hydrolase

4. G. L. Cantoni , The centrality of S-adenosylhomocysteinase in the regulation of the biological utilization of S-adenosylmethionine , in Biological Methylation and Drug Design , ed. R. T. Borchardt , C. R. Creveling and P. M. Ueland , Humana Press , Clifton, NJ , 1986 , pp. 227–238

5. B. T. Keller and R. T.Borchardt , Metabolism and mechanism of action of neplanocin A-A potent inhibitor of S-adenosylhomocysteine hydrolase , in Biological Methylation and Drug Design , ed. R. T. Borchardt , C. R. Creveling and P. M. Ueland , Humana Press , Clifton, NJ , 1986 , pp. 385–396

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