An alternative and efficient synthesis of MLN4924, a selective NEDD8 inhibitor-Reference-Cited by-同舟云学术

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An alternative and efficient synthesis of MLN4924, a selective NEDD8 inhibitor

Published:2019 Issue:14 Volume:6 Page:2480-2487
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Kim Hong-Rae¹²³⁴⁵,Hyun Young Eum¹²³⁴⁵,Jarhad Dnyandev B.¹²³⁴⁵,Yu Jinha¹²³⁴⁵,Jeong Lak Shin¹²³⁴⁵^ORCID

Affiliation:

1. Research Institute of Pharmaceutical Sciences

2. College of Pharmacy

3. Seoul National University

4. Seoul 08826

5. Korea

Abstract

A highly efficient synthesis of MLN4924viaregioselective removal of α-alkoxy group and stereoselective reduction of ketone is described.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/QO/C9QO00507B

Reference34 articles.

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4. Novel Drug Approved for 2018, https://www.fda.gov/drugs/developmentapprovalprocess/druginnovation/ucm592464.htm

5. Drugs Approved in 2018, https://cen.acs.org/sections/drugs-approved-in-2018/index.html

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Asymmetric Synthesis of Fluoro‐MLN4924 as a Selective NEDD8‐Activating Enzyme (NAE) Inhibitor;Asian Journal of Organic Chemistry;2019-08-09

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