Toxicities and beneficial protection of H2S donors based on nonsteroidal anti-inflammatory drugs

Author:

Zhang Jinlong1234,Zhang Qiuping1234,Wang Yanni1234,Li Jili1234ORCID,Bai Zhongjie1234,Zhao Quanyi1234ORCID,Wang Zhen1234,He Dian1234,Zhang Jingke5634,Chen Yonglin734

Affiliation:

1. Institute of Medicinal Chemistry

2. School of Pharmacy of Lanzhou University

3. Lanzhou

4. China

5. GLP Lab Centre, School of Basic Medicine

6. Lanzhou University

7. The First Affiliated Hospital of Lanzhou University

Abstract

Based on our previous study, the H2S donors based on nonsteroidal anti-inflammatory drugs (NSAIDs) were further evaluated including the following aspects: animal blood and urine analyses, liver and kidney toxicities, gastrointestinal protection, anti-hypertension, and myocardial protection.

Funder

Recruitment Program of Global Experts

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

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