Qualitative analysis of antibody–drug conjugates (ADCs): an experimental comparison of analytical techniques of cysteine-linked ADCs
Author:
Affiliation:
1. Department of Chemistry-BMC
2. Analytical Chemistry
3. Uppsala University
4. Uppsala
5. Sweden
6. Department of Medicinal Chemistry
7. Organic Pharmaceutical Chemistry
8. BMC
9. SE-751 23 Uppsala
10. Recipharm OT Chemistry AB
Abstract
Four different cysteine linked antibody-drug conjugates (ADCs) consisting of Trastuzumab-vc-MMAE were analysed with four common analytical techniques with respect to drug-to-antibody ratio (DAR) and molecular weight.
Funder
Stiftelsen för Strategisk Forskning
Vetenskapsrådet
Carl Tryggers Stiftelse för Vetenskaplig Forskning
Publisher
Royal Society of Chemistry (RSC)
Subject
Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/AN/C8AN01178H
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