Synthesis and properties of the kojic acid dimer and its potential for the treatment of Alzheimer's disease-Reference-Cited by-同舟云学术

Synthesis and properties of the kojic acid dimer and its potential for the treatment of Alzheimer's disease

Published:2023 Issue:2 Volume:14 Page:268-276
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Liu Xueyan¹²^ORCID,Yu Chuanyu¹^ORCID,Su Biling¹,Zha Daijun¹²^ORCID

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, Fujian Medical University, Fuzhou 350004, Fujian Province, China

2. Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, Fujian Medical University, China

Abstract

We developed a synthetic route that achieved the gram scale preparation of KAD, and the structure was verified by single crystal X-ray diffraction analysis, and the potential for the multi-target treatment of AD was identified for the first time.

Funder

Fujian Medical University

Natural Science Foundation of Fujian Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D2MD00383J

Reference46 articles.

1. Dual-target compounds for Alzheimer's disease: Natural and synthetic AChE and BACE-1 dual-inhibitors and their structure-activity relationship (SAR)

2. Discovery of Novel Tacrine–Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer’s Disease

3. Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6

4. β-Carboline as a Privileged Scaffold for Multitarget Strategies in Alzheimer’s Disease Therapy

5. The development of advanced structural framework as multi-target-directed ligands for the treatment of Alzheimer’s disease

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