Discovery of Novel Tacrine–Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer’s Disease-Reference-Cited by-同舟云学术

Discovery of Novel Tacrine–Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer’s Disease

Published:2021-05-24 Issue:11 Volume:64 Page:7483-7506
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yao Hong¹,Uras Giuseppe²,Zhang Pengfei¹,Xu Shengtao¹^ORCID,Yin Ying¹³,Liu Jie¹,Qin Shuai¹,Li Xinuo²,Allen Stephanie²,Bai Renren⁴^ORCID,Gong Qi³,Zhang Haiyan³^ORCID,Zhu Zheying²,Xu Jinyi¹^ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China

2. Division of Molecular Therapeutics & Formulation, School of Pharmacy, The University of Nottingham, University Park Campus, Nottingham NG7 2RD, U.K.

3. CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China

4. College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou 311121, China

Funder

China Pharmaceutical University

China Postdoctoral Science Foundation

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

State Key Laboratory of Natural Medicines, China Pharmaceutical University

School of Pharmacy, University of Nottingham

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine