Clickable, acid labile immunosuppressive prodrugs forin vivotargeting

Author:

Wang Hua12345,Sobral Miguel C.12345,Snyder Tracy635,Brudno Yevgeny12345ORCID,Gorantla Vijay S.789105,Mooney David J.12345ORCID

Affiliation:

1. Harvard John A. Paulson School of Engineering and Applied Sciences

2. Harvard University

3. Cambridge

4. Massachusetts 02138

5. USA

6. Wyss Institute for Biologically Inspired Engineering

7. Surgery

8. Ophthalmology and Bioengineering

9. Wake Forest School of Medicine

10. Winston-Salem

Abstract

Clickable immunosuppressive prodrugs enablein vivoreplenishment of drugs in biomaterial depots to maintain long-term immunosuppression in tissue/organ transplantation.

Funder

U.S. Department of State

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Reference52 articles.

1. Current Status of Vascularized Composite Allotransplantation

2. Hand and Upper Extremity Transplantation

3. V. S. Gorantla , J. A.Plock and M. R.Davis , Anesthesia and Perioperative Care for Organ Transplantation , Springer , New York , 2016 , pp. 539–552

4. Historical Overview of Transplantation

5. Immunosuppressive agents in transplantation: Mechanisms of action and current anti-rejection strategies

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