Characterization of a library of vitamin A-functionalized polymethacrylate-based nanoparticles for siRNA delivery-Reference-Cited by-同舟云学术

Characterization of a library of vitamin A-functionalized polymethacrylate-based nanoparticles for siRNA delivery

Published:2021 Issue:6 Volume:12 Page:911-925
ISSN:1759-9954
Container-title:Polymer Chemistry
language:en
Short-container-title:Polym. Chem.

Author:

Klemm Paul¹²³⁴⁵,Huschke Sophie⁵²³⁴⁶,Rodewald Marko⁵²³⁴⁷^ORCID,Ehteshamzad Nadia¹²³⁴⁵,Behnke Mira¹²³⁴⁵,Wang Xinyue⁸²³⁴,Cinar Gizem¹²³⁴⁵^ORCID,Nischang Ivo¹²³⁴⁵^ORCID,Hoeppener Stephanie¹²³⁴⁵^ORCID,Weber Christine¹²³⁴⁵^ORCID,Press Adrian T.⁶⁹¹⁰⁴^ORCID,Höppener Christiane⁷¹¹¹²⁴⁸^ORCID,Meyer Tobias⁷¹¹¹²⁴,Deckert Volker⁵²³⁴⁷^ORCID,Schmitt Michael⁷¹¹¹²⁴⁸,Popp Jürgen⁵²³⁴⁷,Bauer Michael⁵²³⁴⁶,Schubert Stephanie⁵²³⁴¹³^ORCID

Affiliation:

1. Laboratory of Organic and Macromolecular Chemistry (IOMC)

2. Friedrich Schiller University Jena

3. 07743 Jena

4. Germany

5. Jena Center for Soft Matter (JCSM)

6. Department of Anesthesiology and Intensive Care Medicine

7. Leibniz Institute of Photonic Technology Jena

8. Institute of Physical Chemistry and Abbe Center of Photonics

9. Jena University Hospital

10. 07747 Jena

11. Member of Leibniz Health Technologies

12. 07745 Jena

13. Institute of Pharmacy

Abstract

A 60-membered library of vitamin A-functionalized P(MMA-stat-DMAEMA)-b-PPEGMA block copolymers was synthesized by RAFT polymerization. From these, nanoparticles containing genetic material were formulated and fully characterized.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/PY/D0PY01626H

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