Design, synthesis, electrochemistry and anti-trypanosomatid hit/lead identification of nitrofuranylazines-Reference-Cited by-同舟云学术

Design, synthesis, electrochemistry and anti-trypanosomatid hit/lead identification of nitrofuranylazines

Published:2023 Issue:10 Volume:14 Page:2012-2029
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Saayman Maryna¹,Kannigadu Christina¹,Aucamp Janine¹,Janse van Rensburg Helena D.¹,Joseph Cassiem²^ORCID,Swarts Andrew J.²^ORCID,N'Da David D.¹^ORCID

Affiliation:

1. Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, South Africa

2. Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Johannesburg-Braamfontein 2050, South Africa

Abstract

Newly synthesised nitrofuranylazines were screened for antitrypanosomatid activity – 4a and 7a were identified as antileishmanial early leads while 9a was uncovered as antitrypanosomal hit.

Funder

National Research Foundation

North-West University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00220A

Reference71 articles.

1. WHO , Neglected Tropical Diseases: Overview, 2023 , https://www.who.int/health-topics/neglected-tropical-diseases#tab=tab_1 , [Date of access: March 2023]

2. WHO , Neglected tropical diseases: Impact, 2023 , https://www.who.int/health-topics/neglected-tropical-diseases#tab=tab_2 , [Date of access: March 2023]

3. Management of trypanosomiasis and leishmaniasis

4. WHO , Leishmaniasis: Overview, 2023 , https://www.who.int/health-topics/leishmaniasis#tab=tab_1 , [Date of access: March 2023]

5. Leishmaniasis in the Middle East: Incidence and Epidemiology

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