Furoxan–piplartine hybrids as effective NO donors and ROS inducers in PC3 cancer cells: design, synthesis, and biological evaluation-Reference-Cited by-同舟云学术

Furoxan–piplartine hybrids as effective NO donors and ROS inducers in PC3 cancer cells: design, synthesis, and biological evaluation

Published:2024 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Brustolin Braga Carolyne¹^ORCID,Milan Julio Cesar¹,Andrade Meirelles Matheus¹^ORCID,Zavan Bruno²^ORCID,Ferreira-Silva Guilherme Álvaro²^ORCID,Caixeta Ester Siqueira²^ORCID,Ionta Marisa²^ORCID,Pilli Ronaldo A.¹^ORCID

Affiliation:

1. Department of Organic Chemistry, Institute of Chemistry, University of Campinas, UNICAMP, CEP 13083-970, Campinas, Sao Paulo, Brazil

2. Institute of Biomedical Sciences, Federal University of Alfenas, UNIFAL-MG, 37130-001, Alfenas, Minas Gerais, Brazil

Abstract

A novel hybrid integrating piplartine with a furoxan moiety exhibited a sub-micromolar IC50 and extraordinary selectivity for PC3 cells, which was associated with its capacity to release NO, generate ROS, induce DNA damage, and trigger apoptosis.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de São Paulo

Fundação de Amparo à Pesquisa do Estado de Minas Gerais

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00281D

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