Nanoscale, automated, high throughput synthesis and screening for the accelerated discovery of protein modifiers-Reference-Cited by-同舟云学术

Nanoscale, automated, high throughput synthesis and screening for the accelerated discovery of protein modifiers

Published:2021 Issue:5 Volume:12 Page:809-818
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Gao Kai¹²³⁴⁵,Shaabani Shabnam¹²³⁴⁵^ORCID,Xu Ruixue¹²³⁴⁵,Zarganes-Tzitzikas Tryfon¹²³⁴⁵,Gao Li¹²³⁴⁵,Ahmadianmoghaddam Maryam¹²³⁴⁵,Groves Matthew R.¹²³⁴⁵,Dömling Alexander¹²³⁴⁵^ORCID

Affiliation:

1. Pharmacy Department

2. Drug Design group

3. University of Groningen

4. 9700 AD Groningen

5. The Netherlands

Abstract

Acoustic dispensing was used to synthesize 1536 compounds on a nano scale, screened by differential scanning fluorimetry, cross-validated by microscale thermophoresis against the protein interaction menin–MLL to discover binders, one co-crystallized.

Funder

Horizon 2020 Framework Programme

KWF Kankerbestrijding

Center for Scientific Review

Qatar National Research Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00087J

Reference59 articles.