Rapid Affinity and Microsomal Stability Ranking of Crude Mixture Libraries of Histone Deacetylase Inhibitors-Reference-Cited by-同舟云学术

Rapid Affinity and Microsomal Stability Ranking of Crude Mixture Libraries of Histone Deacetylase Inhibitors

Published:2024-09-12 Issue: Volume: Page:
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Tyagarajan Sriram¹,Andrews Christine L.²,Beshore Douglas C.³,Buevich Alexei V.⁴^ORCID,Curran Patrick J.²,Dandliker Peter²,Greshock Thomas J.³^ORCID,Hoar Jason⁵^ORCID,Kim Alex¹,Karnachi Prabha⁶,Knemeyer Ian⁷,Kozlowski Joseph¹,Liu Jian¹,Maletic Milana¹,Myers Robert⁸,Rada Vanessa³,Sha Deyou³,Sauvagnat Berengere²,Vachal Petr¹^ORCID,Wolkenberg Scott³,Yu Wensheng¹,Yu Younong¹,Krska Shane W.¹^ORCID

Affiliation:

1. Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States

2. Quantitative Biosciences, Merck & Co., Inc., Boston, Massachusetts 02115, United States

3. Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

4. Analytical Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

5. Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Rahway, New Jersey 07065, United States

6. Modeling and Informatics, Merck & Co., Inc., Rahway, New Jersey 07065, United States

7. Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Boston, Massachusetts 02115, United States

8. Department of Pharmacology, Merck & Co., Inc., Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.4c00345

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