Taking advantage of lithium monohalocarbenoid intrinsic α-elimination in 2-MeTHF: controlled epoxide ring-opening en route to halohydrins-Reference-Cited by-同舟云学术

Taking advantage of lithium monohalocarbenoid intrinsic α-elimination in 2-MeTHF: controlled epoxide ring-opening en route to halohydrins

Published:2021 Issue:9 Volume:19 Page:2038-2043
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ielo Laura¹²³⁴⁵^ORCID,Miele Margherita¹²³,Pillari Veronica¹²³,Senatore Raffaele¹²³,Mirabile Salvatore⁶⁷⁸⁹¹⁰,Gitto Rosaria⁶⁷⁸⁹¹⁰,Holzer Wolfgang¹²³^ORCID,Alcántara Andrés R.¹¹¹²¹³^ORCID,Pace Vittorio¹²³⁴⁵^ORCID

Affiliation:

1. University of Vienna – Department of Pharmaceutical Chemistry

2. Vienna

3. Austria

4. University of Turin – Department of Chemistry

5. Turin

6. University of Messina – Department of Chemical

7. Biological

8. Pharmaceutical and Environmental Sciences

9. 98168 Messina

10. Italy

11. Complutense University of Madrid – Department of Chemistry in Pharmaceutical Sciences

12. Madrid

13. Spain

Abstract

Lithium monohalocarbenoids are useful synthons for conducting C1-homologations, although their high tendency to undergo degradative α-elimination, leading to a lithium halide and a free carbene, is the main drawback for expanding their use in synthesis.

Funder

Università degli Studi di Torino

Universidad Complutense de Madrid

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D0OB02407D

Reference69 articles.

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2. Stability and reactivity control of carbenoids: recent advances and perspectives