Enantioselective N-heterocyclic carbene-catalyzed synthesis of saccharine-derived dihydropyridinones with cis-selectivity-Reference-Cited by-同舟云学术

Enantioselective N-heterocyclic carbene-catalyzed synthesis of saccharine-derived dihydropyridinones with cis-selectivity

Published:2016 Issue:27 Volume:14 Page:6422-6425
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Liang Zhi-Qin¹²³⁴⁵,Wang Dong-Ling¹²³⁴⁵,Zhang Chun-Lin¹²³⁴⁵,Ye Song¹²³⁴⁵

Affiliation:

1. Beijing National Laboratory for Molecular Sciences

2. CAS Key Laboratory of Molecular Recognition and Function

3. Institute of Chemistry

4. Chinese Academy of Sciences

5. Beijing 100190

Abstract

The N-heterocyclic carbene-catalyzed [2 + 4] cyclocondensation of α-chloroaldehydes and saccharine-derived 1-azadienes was developed, giving dihydropyridinones in good yields with exclusive cis-selectivities and excellent enantioselectivities.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01040G

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1. 3,3-Diphenyl-3-(2-alkyl-1,3,4-oxadiazol-5-yl)propylcycloalkylamines, a novel series of antidiarrheal agents

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