Development of novel enantioselective HPLC methods for the determination of the optical purity of Nα-Fmoc/Boc amino acid derivatives (Nα-PADs) of natural and unnatural amino acids: an analytical strategy for the key starting materials of therapeutic peptides-Reference-Cited by-同舟云学术

Development of novel enantioselective HPLC methods for the determination of the optical purity of Nα-Fmoc/Boc amino acid derivatives (Nα-PADs) of natural and unnatural amino acids: an analytical strategy for the key starting materials of therapeutic peptides

Published:2018 Issue:21 Volume:10 Page:2481-2493
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Komaravolu Yagnakirankumar¹²³⁴⁵^ORCID,Dama Venugopala Rao¹²³⁴⁵,Maringanti Thirumala Chary⁶⁷⁴⁸

Affiliation:

1. Analytical Research and Development

2. IPDO

3. Dr Reddy's Laboratories

4. Hyderabad

5. India – 500090

6. Department of Chemistry

7. Jawaharlal Nehru Technological University

8. India – 500085

Abstract

Chiral HPLC methods for natural and unnatural N^α-Fmoc/Boc amino acid derivatives used in therapeutic peptides.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/AY/C8AY00502H

Reference39 articles.

1. Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide

2. Advances in Fmoc solid‐phase peptide synthesis

3. Food and Drug Administration , ANDAs for certain highly purified synthetic peptide drug products that refer to listed drugs of rDNA origin: draft guidance , 2017

4. Enantiomer separation on monolithic silica HPLC columns using chemically bonded methylated and methylated/acetylated 6-O-tert-butyldimethyl- silylated β-cyclodextrin

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