Construction of 2-alkynyl aza-spiro[4,5]indole scaffolds via sequential C–H activations for modular click chemistry libraries-Reference-Cited by-同舟云学术

Construction of 2-alkynyl aza-spiro[4,5]indole scaffolds via sequential C–H activations for modular click chemistry libraries

Published:2021 Issue:69 Volume:57 Page:8656-8659
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Zhang Jun¹,Wang Mengmeng²,Wang Huiying²,Xu Hui³,Chen Junjie³,Guo Ziqiong³,Ma Biao³,Ban Shu-Rong¹,Dai Hui-Xiong²³⁴^ORCID

Affiliation:

1. School of Pharmaceutical Science, Shanxi Medical University, 56 Xinjian South Road, Taiyuan 030001, China

2. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China

3. Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, Shanghai 201203, China

4. University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

Herein, we have developed a strategy of sequential C–H activations of indole to construct novel 2-alkynyl aza-spiro[4,5]indole scaffolds, which incorporated both alkyne and spiro-units into indole.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D1CC02798K

Reference78 articles.

1. Structure–Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists

2. Peptide–Drug Conjugates with Different Linkers for Cancer Therapy

3. Striking a Balance between Carbonate/Carbamate Linkage Bond- and Reduction-Sensitive Disulfide Bond-Bearing Linker for Tailored Controlled Release: In Situ Covalent-Albumin-Binding Gemcitabine Prodrugs Promote Bioavailability and Tumor Accumulation

4. Probing the Role of the Covalent Linkage of Ferrocene into a Chloroquine Template

5. Combining Molecular Scaffolds from FDA Approved Drugs: Application to Drug Discovery

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Rh(iii)-catalyzed atroposelective C–H alkynylation of 1-aryl isoquinolines with hypervalent iodine–alkyne reagents;Chemical Communications;2024

2. Synthesis of Spirooxindole-1,2-oxazinan-5-ones through 2,2,2-Trifluoroethanol Promoted [3 + 3] Cycloaddition of N-Vinyl Oxindole Nitrones and Oxyallyl Cations;The Journal of Organic Chemistry;2023-11-17

3. Recent progress in alkynylation with hypervalent iodine reagents;Chemical Communications;2023

4. CH Activation of Indoles;Handbook of CH‐Functionalization;2022-10-02

5. Rhodium-Catalyzed C–H Activation of Indoles for the Construction of Spiroindole Scaffolds;Synthesis;2022-03-08