Striking a Balance between Carbonate/Carbamate Linkage Bond- and Reduction-Sensitive Disulfide Bond-Bearing Linker for Tailored Controlled Release: In Situ Covalent-Albumin-Binding Gemcitabine Prodrugs Promote Bioavailability and Tumor Accumulation-Reference-Cited by-同舟云学术

Striking a Balance between Carbonate/Carbamate Linkage Bond- and Reduction-Sensitive Disulfide Bond-Bearing Linker for Tailored Controlled Release: In Situ Covalent-Albumin-Binding Gemcitabine Prodrugs Promote Bioavailability and Tumor Accumulation

Published:2018-05-16 Issue:11 Volume:61 Page:4904-4917
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Huicong¹,Wang Kuanglei²³,Na Kexin¹,Li Dan¹,Li Zhenbao¹,Zhao Dongyang¹,Zhong Lu¹,Wang Menglin¹,Kou Longfa¹,Luo Cong¹,Zhang Haotian⁴,Kan Qiming⁴,Ding Huaiwei⁵,He Zhonggui¹^ORCID,Sun Jin¹^ORCID

Affiliation:

1. Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China

2. Wuyi University, Jiangmen, Guangdong 529020, P. R. China

3. International Healthcare Innovation Institute (Jiangmen), Jiangmen, Guangdong 529080, P. R. China

4. School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China

5. School of Pharmaceutical and Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00293

Reference30 articles.

1. Gemcitabine in metastatic breast cancer

2. Application of ProTide Technology to Gemcitabine: A Successful Approach to Overcome the Key Cancer Resistance Mechanisms Leads to a New Agent (NUC-1031) in Clinical Development

3. Modulation of Gemcitabine (2′,2′-Difluoro-2′-Deoxycytidine) Pharmacokinetics, Metabolism, and Bioavailability in Mice by 3,4,5,6-Tetrahydrouridine

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