Application of ProTide Technology to Gemcitabine: A Successful Approach to Overcome the Key Cancer Resistance Mechanisms Leads to a New Agent (NUC-1031) in Clinical Development

Author:

Slusarczyk Magdalena1,Lopez Monica Huerta1,Balzarini Jan2,Mason Malcolm3,Jiang Wen G.4,Blagden Sarah5,Thompson Emely6,Ghazaly Essam6,McGuigan Christopher1

Affiliation:

1. Cardiff School of Pharmacy & Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, United Kingdom

2. Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, Leuven B-3000, Belgium

3. Section of Oncology & Palliative Medicine, Cardiff University School of Medicine, Velindre Hospital, Cardiff CF14 2TL, United Kingdom

4. Metastasis Research Group, University Department of Surgery, Cardiff University, School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom

5. Department of Oncology, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0HS, United Kingdom

6. Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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