Application of ProTide Technology to Gemcitabine: A Successful Approach to Overcome the Key Cancer Resistance Mechanisms Leads to a New Agent (NUC-1031) in Clinical Development-Reference-Cited by-同舟云学术

Application of ProTide Technology to Gemcitabine: A Successful Approach to Overcome the Key Cancer Resistance Mechanisms Leads to a New Agent (NUC-1031) in Clinical Development

Published:2014-02-14 Issue:4 Volume:57 Page:1531-1542
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Slusarczyk Magdalena¹,Lopez Monica Huerta¹,Balzarini Jan²,Mason Malcolm³,Jiang Wen G.⁴,Blagden Sarah⁵,Thompson Emely⁶,Ghazaly Essam⁶,McGuigan Christopher¹

Affiliation:

1. Cardiff School of Pharmacy & Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, United Kingdom

2. Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, Leuven B-3000, Belgium

3. Section of Oncology & Palliative Medicine, Cardiff University School of Medicine, Velindre Hospital, Cardiff CF14 2TL, United Kingdom

4. Metastasis Research Group, University Department of Surgery, Cardiff University, School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom

5. Department of Oncology, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0HS, United Kingdom

6. Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401853a

Reference51 articles.

1. Synthesis of 2-deoxy-2,2-difluoro-D-ribose and 2-deoxy-2,2'-difluoro-D-ribofuranosyl nucleosides

2. Schedule-dependent therapeutic efficacy of the combination of gemcitabine and cisplatin in head and neck cancer xenografts

3. Comparison of the antitumor activity of gemcitabine and ara-C in a panel of human breast, colon, lung and pancreatic xenograft models

4. Gemcitabine (Gemzar®) in non-small cell lung cancer

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