Synthesis and biological evaluation of 1,2,4-triazoloazines as potent anticancer agents

Author:

Serebrennikova Polina O.1ORCID,Paznikova Julia A.1,Kirnos Eva A.1,Utepova Irina A.123ORCID,Kazakova Elizaveta D.1,Lazarev Vladimir F.4,Kuznetcova Liubov S.4ORCID,Margulis Boris A.4,Guzhova Irina V.4,Chupakhin Oleg N.13ORCID,Sarapultsev Alexey P.2

Affiliation:

1. Department of Organic and Biomolecular Chemistry, Ural Federal University, 28 Mira str., 620002, Ekaterinburg, Russia

2. Russian-Chinese Center of Systemic Pathology, South Ural State University, 76, Lenin Prospekt, Chelyabinsk 454080, Russia

3. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoy str., 620108, Ekaterinburg, Russia

4. Institute of Cytology of the Russian Academy of Sciences, 4 Tikhoretsky av., 194064, St-Petersburg, Russia

Abstract

The new derivatives of mono- and bis-1,2,4-triazoloazines were obtained. The cytotoxic activity of the compounds was evaluated against the cancer cell lines.

Funder

Russian Science Foundation

Ministry of Education and Science of the Russian Federation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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