Quantitative analysis of steric effects on the regioselectivity of the Larock heteroannulation reaction-Reference-Cited by-同舟云学术

Quantitative analysis of steric effects on the regioselectivity of the Larock heteroannulation reaction

Published:2023 Issue:7 Volume:21 Page:1501-1513
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Thangsan Poomsith¹^ORCID,Rukkijakan Thanya¹,Thanaussavadate Bongkotrat¹,Yiamsawat Kanyapat¹,Sirijaraensre Jakkapan²^ORCID,Gable Kevin P.³,Chuawong Pitak¹^ORCID

Affiliation:

1. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Special Research Unit for Advanced Magnetic Resonance (AMR), Kasetsart University, Bangkok 10900, Thailand

2. Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand

3. Department of Chemistry, Oregon State University, 153 Gilbert Hall, Corvallis, Oregon 97331-4003, USA

Abstract

A comprehensive predictive model for regioselectivity in the Larock heteroannulation reaction was constructed. The model provides support for a general blueprint for understanding the steric influence on the reaction selectivity.

Funder

Kasetsart University

Ministry of Higher Education, Science, Research and Innovation, Thailand

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D2OB02089K

Reference96 articles.

1. Synthesis of indoles via palladium-catalyzed heteroannulation of internal alkynes

2. N,N-Dimethylformamide-stabilized palladium nanoclusters as a catalyst for Larock indole synthesis

3. Cluster Preface: Modern Nickel-Catalyzed Reactions

4. Regioselective synthesis of indenones via nickel-catalyzed Larock annulations

5. Mild and efficient synthesis of indoles and isoquinolonesviaa nickel-catalyzed Larock-type heteroannulation reaction

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