Identification of a novel human DNA ligase I inhibitor that promotes cellular apoptosis in DLD-1 cells: an in silico and in vitro mechanistic study
Author:
Affiliation:
1. Molecular and Structural Biology Division
2. CSIR-Central Drug Research Institute
3. Lucknow 226031
4. India
5. Medicinal and Process Chemistry Division
6. Academy of Scientific and Innovative Research (AcSIR)
Abstract
The compound S-097/98 is a specific inhibitor of hLig1. As shown in the figure, the compound inhibits only hLig1 while other human and non-human DNA ligases are not inhibited.
Funder
Science and Engineering Research Board
Department of Biotechnology , Ministry of Science and Technology
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA22364H
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