Synthesis of substituted 2H-benzo[e]indazole-9-carboxylate as a potent antihyperglycemic agent that may act through IRS-1, Akt and GSK-3β pathways-Reference-Cited by-同舟云学术

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Synthesis of substituted 2H-benzo[e]indazole-9-carboxylate as a potent antihyperglycemic agent that may act through IRS-1, Akt and GSK-3β pathways

Published:2017 Issue:2 Volume:8 Page:329-337
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Taneja Gaurav¹²³⁴,Gupta Chandra Prakash¹²³⁴,Mishra Shachi¹²³⁴,Srivastava Rohit⁵²³⁴,Rahuja Neha⁵²³⁴,Rawat Arun Kumar⁵²³⁴,Pandey Jyotsana⁵²³⁴,Gupta Anand P.⁶²³⁴,Jaiswal Natasha⁵²³⁴,Gayen Jiaur R.⁶²³⁴,Tamrakar Akhilesh K.⁵²³⁴,Srivastava Arvind Kumar⁵²³⁴,Goel Atul¹²³⁴

Affiliation:

1. Medicinal and Process Chemistry Division

2. CSIR-Central Drug Research Institute

3. Lucknow 226031

4. India

5. Biochemistry Division

6. Pharmacokinetics and Metabolism Division

Abstract

The synthesis andin vitroandin vivoantihyperglycemic activity of substituted 2H-benzo[e]indazole-9-carboxylate are described.

Funder

Council of Scientific and Industrial Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C6MD00467A

Reference56 articles.

1. Insulin resistance, impaired glucose tolerance and non-insulin-dependent diabetes, pathologic mechanisms and treatment: Current status and therapeutic possibilities

2. Liver Sinusoidal Endothelial Cells Link Hyperinsulinemia to Hepatic Insulin Resistance

3. Amyloid-β Induces Hepatic Insulin Resistance In Vivo via JAK2

4. Solution Structure of the Variable-Type Domain of the Receptor for Advanced Glycation End Products: New Insight into AGE−RAGE Interaction,

5. Social and emotional impact of diabetic retinopathy: a review

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