Design, synthesis, and evaluation of benzofuran-based chromenochalcones for antihyperglycemic and antidyslipidemic activities

Author:

Korthikunta Venkateswarlu1,Singh Rohit123ORCID,Srivastava Rohit4ORCID,Pandey Jyotsana42ORCID,Srivastava Atul4,Chaturvedi Upma4,Mishra Akansha4ORCID,Srivastava Arvind K.4,Tamrakar Akhilesh K.42ORCID,Tadigoppula Narender12ORCID

Affiliation:

1. Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow (U.P.) – 226031, India

2. Academy of Scientific and Innovative Research (AcSIR), Sector 19, Kamla Nehru Nagar Ghaziabad-201002, India

3. Department of Pharmaceutical Chemistry, College of Pharmacy, JSS Academy of Technical Education, C-1/A, Sector-62, Noida, Uttar Pradesh-201309, India

4. Biochemistry and Structural Biology Division, CSIR-Central Drug Research Institute, Lucknow (U.P.) – 226031, India

Abstract

Novel dual acting benzofuran-based chromenochalcones were synthesized and assessed for in vitro and in vivo antihyperglycemic and antidyslipidemic activities.

Funder

Council of Scientific and Industrial Research, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

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