Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles-Reference-Cited by-同舟云学术

Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles

Published:2017 Issue:6 Volume:19 Page:1420-1424
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Huck L.¹²³⁴⁵,Berton M.¹²³,de la Hoz A.⁴⁵⁶³^ORCID,Díaz-Ortiz A.⁴⁵⁶³,Alcázar J.¹²³

Affiliation:

1. Janssen Research and Development

2. Toledo

3. Spain

4. Facultad de Ciencias Químicas

5. Universidad de Castilla-La Mancha

6. Ciudad Real

Abstract

The application of Reformatsky and Blaise reactions for the preparation of a diverse set of valuable intermediates and heterocycles in a one-pot protocol is described.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/GC/C6GC02619B

Reference34 articles.

1. Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

2. The discovery of antibacterial agents using diversity-oriented synthesis

3. Advances in tandem reactions with organozinc reagents

4. Recent advances in the diastereoselective Reformatsky-type reaction

5. Diastereoselective Reformatsky reaction of methyl 4-bromocrotonate with 1,2:5,6-di-O-isopropylidene-α-d-ribo-hexofuranos-3-ulose: application to novel bicyclic nucleosides

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