Experiment-guided molecular simulations define a heterogeneous structural ensemble for the <i>PTPN11</i> tandem SH2 domains-Reference-Cited by-同舟云学术

Experiment-guided molecular simulations define a heterogeneous structural ensemble for the PTPN11 tandem SH2 domains

Published:2023 Issue:21 Volume:14 Page:5743-5755
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Marasco Michelangelo¹^ORCID,Kirkpatrick John²^ORCID,Carlomagno Teresa²³^ORCID,Hub Jochen S.⁴^ORCID,Anselmi Massimiliano⁴^ORCID

Affiliation:

1. Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA

2. School of Biosciences, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK

3. Institute of Cancer and Genomic Sciences, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK

4. Theoretical Physics and Center for Biophysics, Saarland University, 66123 Saarbrücken, Germany

Abstract

We have determined the heterogeneous structural ensemble of the tandem SH2 domains of the protein tyrosine phosphatase SHP2 in agreement with experimental data from small-angle X-ray scattering and NMR residual dipolar couplings in solution.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC00746D

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