Molecular mechanism of SHP2 activation by PD-1 stimulation-Reference-Cited by-同舟云学术

Molecular mechanism of SHP2 activation by PD-1 stimulation

Published:2020-01-31 Issue:5 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Marasco M.¹^ORCID,Berteotti A.²³,Weyershaeuser J.⁴⁵^ORCID,Thorausch N.⁴⁵^ORCID,Sikorska J.⁶^ORCID,Krausze J.¹^ORCID,Brandt H. J.⁴⁵^ORCID,Kirkpatrick J.¹⁶^ORCID,Rios P.³⁴⁵^ORCID,Schamel W. W.⁴⁵⁷,Köhn M.³⁴⁵^ORCID,Carlomagno T.¹²⁶^ORCID

Affiliation:

1. Leibniz University Hannover, Institute of Organic Chemistry and Center for Biomolecular Drug Research, Schneiderberg 38, 30167 Hannover, Germany.

2. European Molecular Biology Laboratory, Structural and Computational Biology Unit, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

3. European Molecular Biology Laboratory, Genome Biology Unit, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

4. Faculty of Biology, Institute of Biology III, University of Freiburg, Schänzlestrasse 18, 79104 Freiburg, Germany.

5. Signalling Research Centers BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.

6. Helmholtz Centre for Infection Research, Group of Structural Chemistry, Inhoffenstrasse 7, 38124 Braunschweig, Germany.

7. Center of Chronic Immunodeficiency CCI, University Clinics and Medical Faculty, Freiburg, Germany.

Abstract

One is not enough: Two PD-1 pTyr motifs bind to SHP2 simultaneously, inducing a conformational change and phosphatase activation.

Funder

European Molecular Biology Organization

Deutsche Forschungsgemeinschaft

MWK Niedersachsen

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference52 articles.

1. The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway

2. Crystal Structure of the Tyrosine Phosphatase SHP-2

3. The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

4. Potent Stimulation of SH-PTP2 Phosphatase Activity by Simultaneous Occupancy of Both SH2 Domains

5. Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis

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