Peptide nano ‘bead-grafting’ for SDT-facilitated immune checkpoints blocking

Author:

Zhang Limin1,Tian Yuwei1,Li Mengzhen1,Wang Minxuan1,Wu Shang1,Jiang Zhenqi1,Wang Qiqin2,Wang Weizhi1ORCID

Affiliation:

1. Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electro-photonic Conversion Materials, School of Chemistry and Chemical Engineering, Institute of Engineering Medicine, Beijing Institute of Technology, Beijing 100081, PR China

2. Institute of Pharmaceutical Analysis, College of Pharmacy, Jinan University, Guangzhou 510632, China

Abstract

Peptide-fibril-captured QDs form nano ‘bead-grafting’, which inhibit both the primary and distant tumors through the combination with immune checkpoint blockade (ICB) and sonodynamic therapy (SDT).

Funder

National Natural Science Foundation of China

Natural Science Foundation of Beijing Municipality

Beijing Institute of Technology Research Fund Program for Young Scholars

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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