Axons-on-a-chip for mimicking non-disruptive diffuse axonal injury underlying traumatic brain injury-Reference-Cited by-同舟云学术

Axons-on-a-chip for mimicking non-disruptive diffuse axonal injury underlying traumatic brain injury

Published:2022 Issue:23 Volume:22 Page:4541-4555
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Pan Xiaorong¹^ORCID,Li Jie²,Li Wei³,Wang Haofei³,Durisic Nela⁴^ORCID,Li Zhenyu¹^ORCID,Feng Yu¹^ORCID,Liu Yifan²^ORCID,Zhao Chun-Xia³⁵^ORCID,Wang Tong¹^ORCID

Affiliation:

1. The Brain Center, School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China

2. Division of Chemistry and Physical Biology, School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China

3. Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia

4. Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia

5. School of Chemical Engineering and Advanced Materials, The University of Adelaide, Adelaide, SA 5005, Australia

Abstract

A microfluidic axon-on-a-chip (AoC) was designed to mimic the axonal injury underlying traumatic brain injury. Diffused axonal injury was modelled by adjusting the flow speed. Instant neuronal responses to the impacts can be resolved using the AoC.

Funder

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

National Health and Medical Research Council

ShanghaiTech University

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/LC/D2LC00730D

Reference54 articles.