Affiliation:
1. NeuroCyto, Aix Marseille Université, CNRS, INP UMR7051 1 , Marseille, France
Abstract
The slender shape of axons makes them uniquely susceptible to mechanical stress. In this issue, Pan, Hu et al. (https://doi.org/10.1083/jcb.202206046) use a microfluidic axon-on-chip device to reveal how actomyosin protects axons from mild mechanical stress, by transiently adopting a beaded shape that helps limit the spread of damaging calcium waves.
Publisher
Rockefeller University Press