Transition-metal-free intramolecular double hydrofunctionalization of alkyne to access 6/7/5-fused heterocyclic skeletons

Author:

Aghaie Kimia1,Amiri Kamran1ORCID,Rezaei-Gohar Mohammad1,Rominger Frank2,Dar’in Dmitry3,Sapegin Alexander3,Balalaie Saeed1ORCID

Affiliation:

1. Peptide Chemistry Research Institute, K. N. Toosi University of Technology, P. O. Box 15875-4416, Tehran, Iran

2. Organisch-Chemisches Institut der Universität Heidelberg, Im Neuenheimer Feld 271, Heidelberg D-69120, Germany

3. Saint Petersburg State University, Saint Petersburg 199034, Russian Federation

Abstract

We have disclosed a novel functionalized isonitrile scaffold containing alkyne moiety and designed a new intramolecular double hydrofunctionalization cyclization of alkyne, that affords access to valuable 6/7/5-fused heterocyclic scaffolds.

Funder

Russian Foundation for Basic Research

Iran National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

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