Why pregnenolone and progesterone, two structurally similar steroids, exhibit remarkably different cocrystallization with aromatic molecules-Reference-Cited by-同舟云学术

Why pregnenolone and progesterone, two structurally similar steroids, exhibit remarkably different cocrystallization with aromatic molecules

Published:2018 Issue:2 Volume:20 Page:898-904
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Luo Ziling¹²³⁴⁵^ORCID,Friščić Tomislav¹²³⁴⁵^ORCID,Khaliullin Rustam Z.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. McGill University

3. 801 Sherbrooke St. West

4. Montreal

5. Canada

Abstract

Selective binding of steroid molecules is of paramount importance for designing drugs that can target the biological pathways of only individual steroids.

Funder

Natural Sciences and Engineering Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CP/C7CP06828J

Reference20 articles.

1. Steroids in Molecular Recognition

2. Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model

3. C. K. Mathews and K. E.Van Holde , Biochemistry , Benjamin/Cummings , Redwood City , 1990

4. Steroid receptor coactivators present a unique opportunity for drug development in hormone-dependent cancers

5. Solid-state dynamic combinatorial chemistry: reversibility and thermodynamic product selection in covalent mechanosynthesis

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