Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd1283.pdf
Reference118 articles.
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3. Meizel, S., Turner, K. O. & Nuccitelli, R. Progesterone triggers a wave of increased free calcium during the human sperm acrosome reaction. Dev. Biol. 182, 67–75 (1997).
4. Schwartz, Z. et al. 1α, 25(OH)2D3 regulates chondrocyte matrix vesicle protein kinase C (PKC) directly via G-protein-dependent mechanisms and indirectly via incorporation of PKC during matrix vesicle biogenesis. J. Biol. Chem. 277, 11828–11837 (2002).
5. Selye, H. Correlations between the chemical structure and the pharmacological actions of the steroids. Endocrinology 30, 437–453 (1942). In the rapid response arena, there were a series of papers from the Selye laboratory in the late 1930s describing a correlation between the chemical structures of steroids and their rapid pharmaco-logical actions as anaesthetics, which are summarized in reference 5.
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