Leukocyte-mimicking nanovesicles for effective doxorubicin delivery to treat breast cancer and melanoma

Author:

Molinaro Roberto12345ORCID,Martinez Jonathan O.1234,Zinger Assaf1234,De Vita Alessandro12346ORCID,Storci Gianluca12347,Arrighetti Noemi12348,De Rosa Enrica1234,Hartman Kelly A.1234,Basu Nupur1234,Taghipour Nima1234,Corbo Claudia12349ORCID,Tasciotti Ennio123410

Affiliation:

1. Regenerative Medicine Program

2. Houston Methodist Research Institute

3. Houston

4. USA

5. School of Pharmacy

6. Osteoncology and Rare Tumors Center

7. Departmentof Experimental

8. Department of Applied Research and Technological Development

9. School of Medicine and Surgery

10. Houston Methodist Orthopedics and Sports Medicine

Abstract

Biomimetic nanovesicles deriving from leukocytes membrane proteins, called leukosomes, exhibit increased targeting of cancer vasculature and stroma by exploiting the inflammatory pathway responsible for recruiting immune cells to the cancer lesion.

Funder

Associazione Bianca Garavaglia

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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